N-{4-[2-(4-Fluorophenyl)-acetyl]-pyridin-2-yl}-acetaMide
Acetamide, N-[4-[(4-fluorophenyl)acetyl]-2-pyridinyl]-
CAS: 452056-81-4
Molecular Formula: C15H13FN2O2
N-{4-[2-(4-Fluorophenyl)-acetyl]-pyridin-2-yl}-acetaMide - Names and Identifiers
N-{4-[2-(4-Fluorophenyl)-acetyl]-pyridin-2-yl}-acetaMide - Physico-chemical Properties
| Molecular Formula | C15H13FN2O2 |
| Molar Mass | 272.27 |
| Melting Point | 140.9℃ |
N-{4-[2-(4-Fluorophenyl)-acetyl]-pyridin-2-yl}-acetaMide - Introduction
Acetamide, N-[4-[(4-fluorophenyl)acetyl]-2-pyridinyl]-is a compound commonly referred to simply as "FPAA". The following describes its nature, use, preparation and safety information:
1. nature:
-Molecular formula: C16H14F2N2O2
-Molecular weight: 316.29g/mol
-Appearance: White or off-white crystalline powder
-Melting point: about 130-135°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane, slightly soluble in ethanol and alcohol solvents
2. use:
FPAA is widely used in the field of medicine, as a pharmaceutical intermediate or organic synthesis reagent. It has anti-cancer, anti-inflammatory and other biological activities, so it is widely used in drug research and manufacturing.
3. Preparation method:
The synthesis of FPAA usually uses chemical synthesis methods, the specific steps are as follows:
-First, pyridine-2-amine and 4-fluorophenylacetic anhydride are reacted by a synthetic method to prepare pyridine-2-one and 4-fluorophenylacetic acid.
-Then, pyridin-2-one and 4-fluorophenylacetic acid are reacted with acetyl chloride to obtain the target product FPAA through acylation reaction.
4. Safety Information:
The relevant safety information for FPAA is as follows:
-need to be sealed in a dry, cool place for storage.
-During operation, avoid prolonged exposure to the air to avoid moisture and oxidation.
-When in use, you need to wear appropriate personal protective equipment, such as gloves and goggles.
- FPAA is an organic compound and should be handled and stored in strict accordance with safe operating procedures. Be sure to read the relevant safety information and operating methods carefully before use.
1. nature:
-Molecular formula: C16H14F2N2O2
-Molecular weight: 316.29g/mol
-Appearance: White or off-white crystalline powder
-Melting point: about 130-135°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane, slightly soluble in ethanol and alcohol solvents
2. use:
FPAA is widely used in the field of medicine, as a pharmaceutical intermediate or organic synthesis reagent. It has anti-cancer, anti-inflammatory and other biological activities, so it is widely used in drug research and manufacturing.
3. Preparation method:
The synthesis of FPAA usually uses chemical synthesis methods, the specific steps are as follows:
-First, pyridine-2-amine and 4-fluorophenylacetic anhydride are reacted by a synthetic method to prepare pyridine-2-one and 4-fluorophenylacetic acid.
-Then, pyridin-2-one and 4-fluorophenylacetic acid are reacted with acetyl chloride to obtain the target product FPAA through acylation reaction.
4. Safety Information:
The relevant safety information for FPAA is as follows:
-need to be sealed in a dry, cool place for storage.
-During operation, avoid prolonged exposure to the air to avoid moisture and oxidation.
-When in use, you need to wear appropriate personal protective equipment, such as gloves and goggles.
- FPAA is an organic compound and should be handled and stored in strict accordance with safe operating procedures. Be sure to read the relevant safety information and operating methods carefully before use.
Last Update：2024-04-09 21:01:54
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